Identification and Reduction of Matrix Effects Caused by Cremophor EL

An analytical technique is a method that is used to determine a chemical or physical property of a chemical substance, chemical element, or mixture. There are a wide variety of techniques used for analysis, from simple weighing (gravimetric analysis) to titrations (titrimetric) to very advanced techniques using highly specialized instrumentation. The most common techniques used in analytical chemistry are the following Titrimetry, (based on the quantity of reagent needed to react with the analyte); Electroanalytical methods,( including potentiometry and voltammetry); Spectroscopy,( based on the differential interaction of the analyte along with electromagnetic radiation); Chromatography,( in which the analyte is separated from the rest of the sample so that it may be measured without interference from other compounds); Gravimetric analysis; Radioanalytical chemistry. There are many more techniques that have specialized applications, and within each major analytical technique there are many applications and variations of the general techniques.
Many scientific endeavors are dependent upon accurate quantification of drugs and endogenous substances in biological samples; the focus of bioanalysis in the pharmaceutical industry is to provide a quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure–response (pharmacokinetics/pharmacodynamics studies). Bioanalysis also applies to drugs used for illicit purposes, forensic investigations, anti-doping testing in sports, and environmental concerns.
Bioanalysis was traditionally thought of in terms of measuring small molecule drugs. However, the past twenty years has seen an increase in biopharmaceuticals (e.g. proteins and peptides), which have been developed to address many of the same diseases as small molecules. These larger biomolecules have presented their own unique challenges to quantification. The Journal is successfully running volume 11 with a large number of viewers from around the world.
OMICS International is using Online Review and Editorial Manager systems for quality review process. Editorial Manager system is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publication. E-mail is sent automatically to concerned persons when significant events occur.
Regards,
Hanna Marin,
Managing editor,
Journal of Analytical and Bioanalytical Techniques
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