The Journal of Clinical and Experimental Pathology (ISSN: 2161-0681) deals with research on infectious disorders associated with immune system and immunological disorders, infectious diseases, treatment of infectious diseases, infectious medicine, epidemiology, diagnostic tests of infectious diseases, infection control, pathophysiology, clinical pathology , preventive medicine. Clinical Pathology deals with patient care, diagnostic services, novel treatments and research on immune infections. Journal of Clinical & Experimental Pathology covers all areas of clinical and experimental pathology. Articles such as research papers, review articles, commentaries and short communications leading to the development of Journal of clinical and experimental pathology.
Immunogenetics is a subspecialty of medicine that studies the relationship between genetics and immunology. Immunogenetics helps in understanding the pathogenesis of several autoimmune and infectious diseases. The term immunogenetics comprises all processes of an organism, which are, on the one hand, controlled and influenced by the genes of the organism, and are, on the other hand, significant with regard to the immunological defence reactions of the organism.
The most important influence on the development of immunogenetics is, however, the studies of a gene family known as the MCH, or major histocompatibility complex. It is a gene family found in many vertebrates. In humans, the “HLA” is interchangeably used with MHC. The MHC gene family is composed of three main subfamilies clustered near one another on chromosome.
MHC class III genes space between MHC class I and class II genes. Glycoproteins encoded by MHC class I genes are present on the surface of all nucleated somatic cells, while the expression of MHC II glycoproteins is largely restricted to the specialized antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. Both have extracellular domains that form the peptide-binding region. Those of MHC class I molecules govern the presentation of peptide (antigen) primarily derived from intracellular sources (endogenous) to CD8+ cytotoxic T lymphocytes (CTLs), while those of MHC class II molecules are particularly effective at presentation of peptide primarily originated from extracellular sources (exogenous) to CD4+ helper T (TH) cells.
Extracellular peptides or pathogens are engulfed by phagocytosis into macrophages and assembled into a vesicle, called phagosome. Lysosomes combine with the phagosome to digest substances in order to extract their antigens.
Other clusters of immune recognition molecules that are well established at the center of the immunogenetics discipline are the large arrays of rearranging gene segments that determine B-cell immunoglobulins and T-cell receptors.
A special focus is often laid on the forecast regarding and therapy of genetically based autoimmune diseases, which include all diseases caused by an extreme reaction of the immune system against the body's own tissue. By mistake, the immune system recognizes the body's own tissue as a foreign object which is to be fought. This can result in serious inflammatory reactions which may permanently damage the respective organs.
The most common chronic diseases afflicting children are asthma, hay fever (allergic rhinitis), and eczema (atopic dermatitis). Due to their strong association with concurrent atopic dermatitis, both asthma and allergic rhinitis can be defined as a type of atopic diseases. In this manner, atopy can be used as an umbrella term that describes a group of diseases, e.g., asthma, allergic rhinitis, food allergy, and urticaria.
Atopy is considered a result of a Th2-mediated process, where Th2 cytokines promote the production of IgE by IgE+ memory B cells and plasma cells. Moreover, there is evidence that genetic factors play a role in determining vaccine safety and adverse events, and consequently, it led to the emergence of adversomics. Overall, vaccinomics and adversomics facilitate prediction of vaccine efficacy and safety by using immunogenetic knowledge, and this in itself helps in developing more effective vaccines.
On the occasion of its 10 years, Successful Journey, Journal of Clinical and Experimental Pathology decided to provide a partial waiver on its article processing charges to promote quality research from across the nations of the globe to encourage the latest research in the field of Infections, Diseases and Medicine. Journal of Clinical and Experimental Pathology also planning to release a special issue on its new approaches.
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