Insights into the Carcinoma

Carcinoma is a malignancy that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis.

Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant. It is from Classification

The cell type from which they start; specifically:

Epithelial cells - carcinoma

Non-hematopoietic mesenchymal cells ⇨ sarcoma

Hematopoietic cells

Bone marrow-derived cells that normally mature in the bloodstream ⇨ leukemia

Bone marrow-derived cells that normally mature in the lymphatic system ⇨ lymphoma

Germ cells -  germinoma

Other criteria that play a role include:

The degree to which the malignant cells resemble their normal, untransformed counterparts

The appearance of the local tissue and stromal architecture

The anatomical location from which tumors arise

Genetic, epigenetic, and molecular features

Pathogenesis

Cancer occurs when a single progenitor cell accumulates mutations and other changes in the DNA, histones, and other biochemical compounds that make up the cell's genome. The cell genome controls the structure of the cell's biochemical components, the biochemical reactions that occur within the cell, and the biological interactions of that cell with other cells. Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) displaying a number of abnormal, malignant cellular properties that, when taken together, are considered characteristic of cancer, including:

the ability to continue to divide perpetually, producing an exponentially (or near-exponentially) increasing number of new malignant cancerous "daughter cells" (uncontrolled mitosis);

The ability to penetrate normal body surfaces and barriers, and to bore into or through nearby body structures and tissues (local invasiveness);

The ability to spread to other sites within the body (metastasize) by penetrating or entering into the lymphatic vessels (regional metastasis) and/or the blood vessels (distant metastasis).

If this process of continuous growth, local invasion, and regional and distant metastasis is not halted via a combination of stimulation of immunological defenses and medical treatment interventions, the end result is that the host suffers a continuously increasing burden of tumor cells throughout the body. Eventually, the tumor burden increasingly interferes with normal biochemical functions carried out by the host's organs, and death ultimately ensues.

Carcinoma is but one form of cancer—one composed of cells that have developed the cytological appearance, histological architecture, or molecular characteristics of epithelial cells.  A progenitor carcinoma stem cell can be formed from any of a number of oncogenic combinations of mutations in a totipotent cell,  a multipotent cell,  or a mature differentiated cell

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Best Regards

Eliza Grace

Journal Manager

Journal of Surgical Pathology and Diagnosis