Pathology and Diagnosis of Central Nervous System Infections


Infections of the central nervous system (CNS) are important because of the many pathogens, the emerging and reemerging of new infections, and the heavy burden they impose on health care system. The most formidable challenge is the increasing number of people at risk of developing CNS infections due to acquired immunodeficiency syndrome (AIDS) and the recipients of hemopoietic and solid organ transplantation and other causes of immunosuppression. There have been significant developments in the last few decades in understanding the biology of disease process by the application of new technologies. Advancements in brain imaging and newer diagnostic modalities have achieved early diagnosis helping patient management with new therapies. The pathogenetic factors contributing to neurovirulence of the pathogens have been elucidated by the use of molecular biological techniques.

The infections are caused by wide variety of organisms including bacteria, parasites, fungi, and viruses. The clinical course may be acute, subacute, or chronic depending on the pathogen, location, and immune status of the host. The clinical manifestations are protean.

The normal brain is a highly complex and specialized organ. It is protected by bony encasement of skull and thick dura mater. However, this encasement limits its capacity to swell in case of inflammation. Another important defense for brain is in the form of blood brain barrier (BBB), made up of a system of tight junctions in capillaries that resist the entry of the inflammatory cells, pathogens, and macromolecules into the subarachnoid space. The brain has a rudimentary lymphatic system. The microglia and perivascular macrophages have much lower expression of major histocompatibility complex (MHC) molecules. This helps the pathogen by poor antigen presentation to body's immune system and greater survival.

The Journal of Clinical and Experimental Pathology (ISSN: 2161-0681) deals with research on infectious disorders associated with immune system and immunological disorders, infectious diseases, treatment of infectious diseases, infectious medicine, epidemiology, diagnostic tests of infectious diseases, infection control, pathophysiology, clinical pathology , preventive medicine. Clinical Pathology deals with patient care, diagnostic services, novel treatments and research on immune infections. Journal of Clinical & Experimental Pathology covers all areas of clinical and experimental pathology. Articles such as research papers, review articles, commentaries and short communications leading to the development of Journal of clinical and experimental pathology.

On the occasion of its 10 years, Successful Journey, Journal of Clinical and Experimental Pathology decided to provide a partial waiver on its article processing charges to promote quality research from across the nations of the globe to encourage the latest research in the field of Infections, Diseases and Medicine. Journal of Clinical and Experimental Pathology also planning to release a special issue on its new approaches.
Robert Solomon
Editorial office
Journal of Clinical and Experimental Pathology