SARS-CoV-2 is a positive-sense group β coronavirus. It is single-stranded with a genome of around 30 kbp. The genome of the virus contains ten open-reading frames (ORFs) that encode Spike, Membrane, Envelope, and the nucleocapsid proteins which are the four structural proteins, and six nonstructural proteins such as ORF1ab, ORF3, ORF6, ORF7, ORF8, and ORF10.

Research demonstrated that mitochondrial translation machinery plays an important phase in the viral protein translation. It was then widely understood that viruses effectively interact with mitochondrial receptors to inhibit mitochondrial antiviral signalling processes. This in turn this induces mitochondrial stress that facilitates the survival and replication of viruses. Mitochondrial vesicles are formed, that act as a replication niche for the virus as they regulate the production of ATP, cellular differentiation , apoptosis, and antiviral immune activation.

They concluded that Mitochondrial-targeting drugs have strong potential as antiviral therapeutic reagents as mitochondria-targets significantly repress rare codon-driven gene expression and viral replication.

Diagnostic Pathology: Open Access is collecting manuscripts all over the globe on COVID-19 to endorse the advancement of current knowledge pertaining to clinical studies and scientific investigations and foster discussion in all the relevant aspects of Pathology such as Immunopathology, Virtual Pathology, Tissue based Diagnosis, Immunohistochemistry, Diagnostic Pathology of Infectious Diseases.

We have also announced a Special Issue on “Therapeutic Applications in COVID-19” acknowledging the significance in the Global Scientific Community. The Special Issue is being edited by our honourable Executive Editorial Chair Person Dr. Maria Teresa Mascellino. The Submissions are Open!

Regards,

Matthew Richard
Diagnostic Pathology: Open Access
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